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KMID : 0360220210620070895
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 7 p.895 ~ p.903
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Assessment of the Compliance with 0.1% Cyclosporine A in Dry-Eye Patients with Sjogren's Syndrom
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Park Do-Hee
Jin Hyung-Nam
Yoon Hee-Su
Yoon Hyeon-Jeong
Yoon Kyung-Chul
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Abstract
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Purpose: To evaluate the compliance with 0.1% cyclosporine A in dry eye patients with Sjogren's syndrome and identify factors affecting the compliance.
Methods: This study included 67 dry eye patients with Sjogren's syndrome who had used 0.1% cyclosporine A for over 6 months.
Clinical parameters including sex, age, the number of eye drops used, side effects, the use of steroid eye drops, and the visit interval were investigated. Additionally, the ocular surface disease index, tear break-up time (TBUT), Schirmer test score, and corneal fluorescein staining (CFS) score were assessed. Patients were classified into compliant and non-compliant groups, using a criterion of 50% compliance; relevant factors were evaluated accordingly.
Results: Of the 67 patients, 36 (53.7%) were classified into the compliant group and 31 (46.3%) into the non-compliant group. Compared to the non-compliant group, the compliant group showed a longer TBUT (p = 0.03) and a lower CFS score (p = 0.04) at 6 months of follow-up. Altogether, 39 subjects (58.2%) experienced side effects, of which the most common was stinging pain (71.8%). In the multivariate analysis, severe dry-eye symptoms (p = 0.03), non-use of the steroid eye drops (p = 0.02), and longintervals between exam vitists (p = 0.02) were identified as factors reducing compliance.
Conclusions: Factors related to a decrease in the compliance with 0.1% cyclosporine A in dry-eye patients with Sjogren's syndrome, included severe dry eye symptoms, long visit intervals, and non-use of steroid eye drops. Taking these factors into consideration may help increase patient compliance.
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KEYWORD
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Cationic emulsion, Compliance, Cyclosporine A, Dry eye, Sjogren's syndrome
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